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Her 2

Name. HER2 is so named because it has a similar structure to human epidermal growth factor receptor, or HER1. Neu is so named because it was derived from a rodent glioblastoma cell line, a type of neural tumor. ErbB-2 was named for its similarity to ErbB (avian erythroblastosis oncogene B), the oncogene later found to code for EGFR.Molecular cloning of the gene showed that HER2, Neu, and ErbB. HER2 is a growth-promoting protein on the outside of all breast cells. Breast cancer cells with higher than normal levels of HER2 are called HER2-positive. These cancers tend to grow and spread faster than other breast cancers, but are much more likely to respond to treatment with drugs that target the HER2 protein HER2 (human epidermal growth factor receptor 2) is a gene that can play a role in the development of breast cancer.Your pathology report should include information about HER2 status, which tells you whether or not HER2 is playing a role in the cancer. Genes contain the recipes for the various proteins a cell needs to stay healthy and function normally HER2-positiv bröstcancer. Omkring 13 % av alla bröstcancerpatienter drabbas av HER2-positiv bröstcancer 1.HER2-positiv innebär ett överuttryck av tillväxtfaktorreceptorn human epidermal growth factor receptor 2 (HER2) eller ett ökat antal kopior av HER2-genen i tumörcellerna

HER2/neu - Wikipedi

Breast Cancer HER2 Status HER2 Positive Breast Cance

HER2/neu (C-erb B-2) overexpression has been found in 25% to 88% of SDCs (Fig. 9.27). 251 Whether it has prognostic significance, however, is controversial. In one study of HER 2-neu and SDC, Skalova and colleagues 252 observed that 8 of 11 cases showed strong distinct membrane staining for this marker (score 3+) with immunohistochemistry, while the remaining three cases were inconclusive with. Elisabet Lidbrink säger: En bröstcancer som är HER2--positiv och som kommer tillbaka i form av metastaser t.ex. i lever, lunga eller skelett bör i första hand behandlas med antikroppen.

HER2 Status: Tests, Treatments, and Mor

HER2 er et protein som fungerer som reseptor for epidermal vekstfaktor (epidermal growth factor, EGF). Genet er oppregulert i om lag 30 prosent av brystkreftsvulster. Når HER2-genet er oppregulert vil kreftsvulsten kunne vokse ekstra hissig med stor celletilvekst. HER2 påvises i vevsprøver av svulsten. HER2 is short for the human epidermal growth factor receptor 2. (It is also known as ERBB2). In some cancers, especially breast cancer or cancers of the stomach and esophagus (gastroesophageal), the tumor cells have extra copies of the gene and excess amounts of the protein that it produces. Tumors in this category are known as HER2-positive and can be more aggressive and respond differently. HER2-positiv bröstcancer innebär att cancercellerna gör för mycket HER2, vilket kan göra att tumörer växer mer aggressivt än med andra former av bröstcancer. Lyckligtvis finns det speciella mediciner som riktar sig till HER2. Ditt onkologiska team kan referera till dessa läkemedel som riktad terapi eller HER2-riktad behandling

Målinriktad terapi vid HER2-positiv bröstcancer

  1. Precis som när man misstänker HER2-positiv bröstcancer så undersöker man HER2-statusen hos cancercellerna. Först efter att tumören har konstaterats vara okänslig för hormoner och HER2 anses den vara trippelnegativ. I övrigt är testerna som används för att diagnostisera trippelnegativ bröstcancer samma som vid andra bröstcancerformer
  2. This is known as HER2 positive breast cancer. Around one in five invasive breast cancers (breast cancer that has the potential to spread to other parts of the body) are HER2 positive. How do I know if my breast cancer is HER2 positive or HER2 negative? All invasive breast cancers are tested for HER2 levels
  3. HER2+ 2019-06-19. Hej ! Jag har HER2 + ingen spridning. Min diagnos ser ut så här. Invasiv Ductal cancer HER 2 positiv, grad 3 tumör. 23 mm. Ki-67 63,5 % ER 90% Har gjort Mastetkomi 15/4 . Ej spridd cancer
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HER-2 Blockad. Tionde nordiska symposiet om HER2-positiv bröstcancer. Av Anders Nystrand, Foto Jan Torbjörnsson. 31 jan 2018. Etiketter:ANDERS NYSTRAND, APHINITY, Bröstcancer, Foto Jan Torbjörnsson, HER-2, HER-2 Blockad, trastuzumab. Vilka strategier för HER2-blockad är mest optimala i olika behandlingsfaser av HER2- positiv bröstcancer HER2: A gene on chromosome 17q11.2-q12 that encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ERBB2 has no ligand-binding domain and thus cannot bind growth factors; it does, however, bind to other ligand-bound EGF receptor family members, forming a heterodimer, stabilising ligand binding and. HER-2: A gene on chromosome 17q11.2-q12 that encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ERBB2 has no ligand-binding domain and thus cannot bind growth factors; it does, however, bind to other ligand-bound EGF receptor family members, forming a heterodimer, stabilising ligand binding and.

Video: Förstå en HR + eller HER2-bröstcancerdiagnos - 202

HER2 inhibitors (inhibiting targets of signaling pathways) used for various assays, some have entered clinical trials, which would be new cancer therapies HER2-positiv bröstcancer anses vara mer aggressiv än den hormonkänsliga varianten och upptäcks med ett vävnadsprov 3. När man vet att tumören är HER2-positiv kan den behandlas med en typ av målinriktade läkemedel, sk monoklonala antikroppar. Läs mer om HER2-positiv bröstcancer här . Trippelnegativ bröstcance Listen to Vol. 1 & 2 along with The B Sides: http://smarturl.it/Vol2BSides?IQid=yt Follow H.E.R. https://twitter.com/HERMusicx https://www.instagram.com/herm.. Inflammatorisk cancer som är her2 positiv men min är hormon negativ. Fick min diagnos maj 09 och räknas nu som tumörfri. 2-3 procent av alla med bröstcancer har inflammatorisk bröstcancer och 20 procent av alla bröstcancer diagnoser är her2 positiva så det är en mycket ovanlig diagnos. Ska följa din blogg. Kram. Svara Rader Synonyme: human epidermal growth factor receptor 2, HER2, erb-B2, c-erbB2. 1 Definition. Als HER2/neu bezeichnet man sowohl einen Wachstumsfaktor-Rezeptor als auch das zugehörige Gen auf Chromosom 17.In bis zu 20 % aller Fälle von Mammakarzinom findet sich eine Alteration des HER2/neu-Gens und eine Überexpression des zugehörigen HER2/neu-Rezeptors auf der Zelloberfläche von Karzinomzellen

Directed by Spike Jonze. With Joaquin Phoenix, Amy Adams, Scarlett Johansson, Rooney Mara. In a near future, a lonely writer develops an unlikely relationship with an operating system designed to meet his every need 2 available now when you pre-order Vol. 2 - The B sides: http://smarturl.it/Vol2BSides?IQid=yt Follow H.E.R. https://twitter.com/HERMusicx https://www.inst..

Tionde nordiska symposiet om HER2-positiv bröstcancer: Vilka strategier för HER2-blockad är mest optimala i olika behandlingsfaser av HER2- positiv bröstcancer?Är till exempel adjuvant HER2-blockad i bara nio veckor eller sex månader för vissa patientgrupper lika bra som nuvarande standardbehandling i tolv månader?Och kan en ny HER2-avbildningsteknik bli ett hjälpmedel för att. HER2 är en gen som skapar HER2-proteiner eller receptorer. Dessa receptorer hjälper till att kontrollera tillväxt och reparation av bröstceller. En överuttryck av HER2-proteinet orsakar out-of-control-reproduktion av bröstceller. HER2-positiva bröstcancer tenderar att vara mer aggressiv än HER2-negativa bröstcancer HER2 är namnet på ett protein vars huvudsakliga uppgift är att reglera celldelning och cellväxt. Om det blir för många av de gener som producerar HER2 tillverkas alltför mycket HER2 protein, och celldelningen ökar och blir okontrollerad

HER2-Positive Breast Cancer: Symptoms, Diagnosis

The HER2-positive breast cancer treatment that is right for you will depend on several factors, including whether your tumor is also estrogen-receptor positive, where the cancer has metastasized to, and what treatment you received in the past if you were previously HER2-positive HER2+ breast cancer survival rates tell you how many women survive for a certain time after their diagnosis. But that's just part of the picture. Find out what this statistic means and what. HER2-positiv bröstcancer . I ca 20\% av bröstcancerna gör cellerna för mycket av ett protein som är känt som HER2. Dessa cancerformer tenderar att vara aggressiva och snabbt växande. För kvinnor med HER2-positiva bröstcancer har läkemedlet trastuzumab (herceptin) visat sig dramatiskt minska risken för att cancer återkommer

Bröstcancer - Symtom, orsaker och behandling Cancerfonde

HER2/neu, c-erbB2 (Human Epidermal Growth Factor Receptor 2) Genom genamplifikation överuttrycks denna tillväxtfaktorreceptor vars ökade förekomst är korrelerad till hög cellproliferation. Förekomst av HER2-receptorerna i cellytan påvisas immunhistokemiskt och kvantifieras i grader mellan 0 till 3+ HER2-positiv bröstcancer. Vid HER2-positiv bröstcancer kan läkemedel riktade mot HER2-proteinet användas, eftersom proteinet driver på cancertillväxten. Antikroppar som kallas trastuzumab och pertuzumab som blockerar HER2 används som behandling. Somliga får behandling både före och efter operation HER2 is the more common name for the gene called ERBB2. HER2 (or HER2/neu) stands for human epidermal growth factor receptor 2. The job of HER2 is to control a protein on the surface of cells that helps them grow. If the HER2 gene changes, it may help a tumour grow. Healthy cells have 2 copies of the HER2 gene We teach you why HER2-positive breast cancers are more threatening and educate you about new therapies such as targeted immunotherapy and neoadjuvant chemoth..

HER2/neu (human epidermal growth factor receptor 2, offizieller Name: ERBB2, erb-b2 receptor tyrosine kinase 2) gehört zur Familie der epidermalen Wachstumsfaktorrezeptoren (EGF-Rezeptor).HER2/neu stimuliert die Zellproliferation über den RAS-MAP-Kinase-Weg und hemmt den programmierten Zelltod (Apoptose) über den mTOR-Signalweg. Neben seiner sehr bekannten Verwendung bei Mammakarzinomen. HER2-positive breast cancers have abnormally high levels of HER2 receptors, whereas HER2-negative breast cancers don't. There are a few differences between HER2-positive and HER2-negative breast cancers, including the tumor's risk factors, its biology, and its anticipated aggressiveness

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HER2-positive breast cancer: What is it? - Mayo Clini

  1. HER2-positiv bröstcancer är en aggressiv form av bröstcancer med ökad risk för spridning och återfall. I Sverige drabbas årligen cirka 9 000 kvinnor av bröstcancer
  2. HER2 overexpression (by IHC or FISH) identifies patients who might derive benefit from HER2 targeted therapy Trastuzumab based chemotherapy in patients with HER2 overexpression results in prolongation in median survival, progression free survival, overall response rate, clinical benefit rate and duration of response ( Lancet 2010;376:687
  3. Spectrum Pharmaceuticals Presents Results in HER2 Exon 20 Insertion Mutations from Cohort 2 of the Poziotinib ZENITH20 Clinical Trial September 18, 2020 07:00 AM Eastern Daylight Tim
  4. HER-2, gp100, and MAGE-1 mRNA expression was detected in 81.4%, 46.5%, and 39.5% of the GBM primary cell lines, respectively. Using immunoreactive staining analysis by flow cytometry, HER-2, gp100, and MAGE-1 protein expression was detected in 76%, 45%, and 38% of the GBM primary cell lines, respectively
  5. avslutad_PREDIX HER 2. Svensk titel. Neoadjuvant responsledd behandling av HER2-positiv bröstcancer. Del av flera translationella fas 2-studier baserade på molekylär subtypning. Fullständig protokollstitel. Neoadjuvant respons-guided treatment of HER2 positive breast cancer
  6. HER-2 (c-erbB2, neu) receptor is the molecular marker of ductal breast cancer although it is verexpressed in other adenocarcinoma as well (e.g.endometrial, colorectal and lung cancers). The increased receptor expression is most frequently (90-97%) due to gene amplification. Detection of the overexpr

In a Los Angeles of the slight future, a lonely writer develops a relationship with Samantha, an insightful and sensitive artificial entity. Watch trailers & learn more Ona se često naziva HER2 (od engl. human epidermal growth factor receptor 2) ili HER2/neu. HER2 je član familije receptora epidermalnih faktora rasta (HER/EGFR/ERBB). Amplifikacija ili prekomerno izražavanje ovog onkogena ima važnu ulogu u razviću i progresiji pojedinih agresivnih tipova raka dojke

HER2-Positive Breast Cancer Survival Rates: Statistics & Mor

  1. Human epidermal growth factor receptor 2 (HER2) is a member of the epidermal growth factor receptor family having tyrosine kinase activity. Dimerization of the receptor results in the autophosphorylation of tyrosine residues within the cytoplasmic domain of the receptors and initiates a variety of signaling pathways leading to cell proliferation and tumorigenesis
  2. Vi skulle vilja visa dig en beskrivning här men webbplatsen du tittar på tillåter inte detta
  3. The human HER2 gene with the generic name ERBB2 (also known as NEU) encodes the HER2 protein or p185HER2. The HER2 protein is a membrane receptor tyrosine kinase with homology to the epidermal growth factor receptor (EGFR). The HER2 gene is a normal component present in two copies in all normal diploid cells. In a fraction of patients (15-20%) with breast cancer, the HER2 gene is amplified as.

HER2 är en viktig tillväxtfaktorreceptor, ett protein, som finns på ytan hos de flesta av kroppens celler, vars uppgift är att reglera cellens tillväxt och delning. Vid HER2-positiv. Moved Permanently. The document has moved here

HER2 is a protein found on breast cells. It is involved in normal cell growth. In some cancers, the cells have too much HER2 protein. These are known as HER2-positive cancers. HER2 testing can show whether you have HER2-positive cancer. Treatments for HER2-positive cancer can be very effective. Learn more HER2-positive breast cancer is more aggressive than other types of breast cancer. Changes in the HER2 gene, can lead to cell and tumor growth, but effective treatment is available. Find out more. ErbB2 (HER2) is a receptor tyrosine kinase that is overexpressed in some breast tumors. Herceptin, used in treatment of metastatic Her2-positive cancer, is monoclonal antibody targeting this kinase

HER2/neu - an overview ScienceDirect Topic

Her-2/neu amplification increases with increasing grade of breast cancer. A high proportion of Her-2/neu gene amplified cases indicates aggressive disease in that area and need for FISH testing on large scale, which is the gold standard for equivocal cases on immunohistochemistry New Mom Wants Her 2 Extra Nipples Removed. Six months after giving birth, Tyler is ready to only have two nipples instead of four. Good thing she chose Dr. Cat--who's had the same surgery Mom speaks out after investigators say her 2-year-old son shot himself Click here for updates on this story MILWAUKEE ( WDJT ) — Two-year-old Rashad Isola has been in the hospital for 57 days Actress Tia Mowry shared recipes for the collard greens, cornbread and rosemary pear Bellini she'll be serving as part of her traditional Thanksgiving menu

Samsung RB31HER2CSA Grå - Hitta lägsta pris hos PriceRunner Jämför priser från 2 butiker Betala inte för mycket - SPARA på ditt inköp nu HER2-positive breast cancer is a cancer that tests positive for a protein called human epidermal growth factor receptor 2 (HER2), which promotes the growth of tumour cells The VENTANA HER2 Dual ISH assay is easily interpreted using brightfield microscopy 2 which has proven concordance with FISH 1 enabling every lab the ability to run testing in-house that allows for faster results to the oncologist and their patient.. To evaluate the clinical sensitivity and specificity of the VENTANA HER2 Dual ISH DNA Probe Cocktail assay in determination of HER2 gene status in.

Får man oftare återfall med HER2-bröstcancer? Aftonblade

  1. HER2-positiv bröstcancer I grunden en mycket aggressiv tumörtyp med snabb tillväxt. Tillkomsten av effektiv anti-HER-2 behandling som tillägg till cytostatika har dock inneburit att denna subgrupp har den bästa prognosen, med många fall av komplett remission under långa perioder
  2. HER2-positive breast cancer An aggressive type of breast cancer Breast cancer: a global problem Breast cancer is the most common cancer among women.1 Each year about 1.6 million new cases are diagnosed worldwide, and over 500,000 women will die of the disease.1 This means that one woman is diagnosed with breast cancer somewhere in the world every 20 seconds and more than three women die of.
  3. ars in Surgical Oncology 2008;5:9) The biologic impact of HER2 gene amplification is not due to.

HER2 - Store medisinske leksiko

  1. Tyrosine kinase inhibitors bind to the tyrosine kinase domain in the HER2 and stops activation of the signaling pathway. Monoclonal antibodies bind to the extracellular component of the HER2, prevent the actual substrates from binding to the receptors and stop the receptor activation. HER2 inhibitors are used in the treatment of breast cancer
  2. HER2 stands for human epidermal growth factor receptor 2. The term HER2 may refer to the HER2 gene or to the protein HER2, which the gene makes.. HER2 proteins are receptors that sit on the.
  3. HER2 heterogeneity and polysomy in gastric cancer. (a-c) Biopsy material comprising around eight samples endoscopically removed. (a) Strong HER2 expression in only two of the biopsy samples.
  4. TAK-285 is an investigational HER2/EGFR inhibitor that penetrates the CNS in Rats with an Intact Blood Brain Barrier (BBB). TAK-285 has inhibitory activity against HER2 and EGFR kinases with IC50 values for HER2 and EGFR of 17 nmol/L (95% CI 12-24) and 23 nmol/L (95% CI 18-30), respectively.[1] Learn Mor
  5. Sara M. Tolaney, MD, MPH, discusses the challenges in treating patients with heterogenous HER2 expression and what treatments could potentially improve outcomes for this subgroup
  6. Serum HER-2/neu testing can identify HER-2/neu positive patients previously classified as negative by tissue testing. American Association for Clinical Chemistry Annual Meeting Proceedings, 2008. Clin Chem Vol 54(56) Suppl, Pg A130: Abstract No. C-96
  7. Her-2 is a story of dramatic discoveries and strong personalities, showing the combination of scientific investigation, money, politics, ego, corporate decisions, patient activism, and luck involved in moving this groundbreaking drug from the lab to a patient's bedside

HER2 - Understand the Test - Lab Tests Onlin

Herceptin: Indications Adjuvant Breast Cancer. Herceptin is approved for the treatment of early-stage breast cancer that is Human Epidermal growth factor Receptor 2-positive (HER2+) and has spread into the lymph nodes, or is HER2-positive and has not spread into the lymph nodes.If it has not spread into the lymph nodes, the cancer needs to be estrogen receptor/progesterone receptor (ER/PR. The ErbB family of proteins contains four receptor tyrosine kinases, structurally related to the epidermal growth factor receptor (EGFR), its first discovered member.In humans, the family includes Her1 (EGFR, ErbB1), Her2 (Neu, ErbB2), Her3 (), and Her4 ().The gene symbol, ErbB, is derived from the name of a viral oncogene to which these receptors are homologous: erythroblastic leukemia viral. When women call the SHARE helpline and tell me they've just been diagnosed with HER2-positive breast cancer, I know how scared they are.Often they've consulted Dr. Google and learned that HER2-positive cancers are especially aggressive and likely to recur In subsets of patients with cancer HER-2 is over-expressed including subsets of breast, gastric, pancreatic, brain, lung, and colon cancer. This trial is designed for compassionate use of a HER-2/neu pulsed DC1 in patients with metastatic HER-2 positive cancer, who have no longer standard options to eliminate disease

HER2-positiv bröstcancer-kemoterapi 202

HER2 expression. The HER2 immunostaining was localized in the membranes of tumor cells. In total, HER2 positivity was detectable in 12.2% (n = 44) of interpretable EAC cases on the single-spot TMA.On the multi-spot TMA, HER2 expression was found in 24 patients (14.9%) on the surface area and in 18 patients (10.9%) at the infiltration margin HER2 gene amplification, or protein overexpression, is still considered a major mechanism of HER2-driven tumorigenesis and is used as a main predictive biomarker to identify patients who might benefit from therapy with anti-HER2 agents. There are, thus, many different cancer drugs approved by the US Food and Drug Administration (FDA) that target the deregulation of HER2, including monoclonal. HER2/ErbB2 Antibody detects endogenous levels of total ErbB2 protein. The antibody does not cross-react with related kinases. Species Reactivity: Human. Source / Purification. Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Tyr1222 of human ErbB2

KISQALI ® (ribociclib) is a prescription medicine used in combination with:. an aromatase inhibitor to treat pre/perimenopausal or postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer that has spread to other parts of the body (metastatic), as the first endocrine-based therapy; o Additionally, HER2 status has been shown to be predictive for response to certain chemotherapeutic agents (ie, doxorubicin [Adriamycin]; and HER2-targeted therapies trastuzumab, pertuzumab, and lapatinib [Tykerb, a small-molecule oral tyrosine kinase inhibitor directed specifically to the HER2 receptor]) HER2-positiv, tidig bröstcancer som inte uppnått patologisk komplett respons efter neoadjuvant behandling. Det primära effektmåttet för studien var invasiv sjukdomsfri överlevnad (IDFS) och Kadcyla visades ge en statistiskt signifikant högre IDFS jämfört med trastuzumab (HR = 0,50, 95 % K HER-2/neu; A HER2 positive cancer is good news, because it allows them to treat with Herceptin, a Very effective medicine. 'HER2 positivity' refers to the tumor cells having extra copies of the HER2 gene and/or increased levels of expression of the HER2 protein Her2 expression is associated with a diminished prognosis. Her2 positive patients are generally treated with anthracyclines and taxane-based chemotherapies and Her2 targeted therapies such as Herceptin® (J9355). ER, PR, and Her2 testing may be reported with a variety of codes, depending on the methodology. Table 2 provides the available coding.

Allt om trippelnegativ bröstcancer Spridd bröstcance

NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine När man studerar Her2-avbildningen baserad på Lumitos teknologi är det enkelt att förstå möjligheterna för patologerna att se endast vävnad av intresse. Tekno erbjuder också potential för bildanalys som kan bli till hjälp i framtiden vid införandet av automatiserade diagnoser. Stefan Nilsson, V 301 Moved Permanently. openrest Purpose: ONT-380 (ARRY-380) is a potent and selective oral HER2 inhibitor. This Phase I study determined the MTD, pharmacokinetics (PK) and antitumor activity of ONT-380 in HER2-positive advanced solid tumors, with an expansion cohort of patients with HER2+ MBC. Experimental Design: ONT-380 was administered twice daily (BID) in continuous 28-day cycles

HER2 Breast Cancer No

HER2-positive breast cancers have a lot of HER2 protein. You also may hear the term HER2 over-expression. HER2-negative breast cancers have little or no HER2 protein. About 10-20 percent of newly diagnosed breast cancers are HER2-positive . HER2 status is part of breast cancer staging and helps guide your treatment use prior to surgery (neoadjuvant treatment) in people with HER2-positive, locally advanced, inflammatory, or early stage breast cancer (tumor is greater than 2 cm in diameter or node-positive). PERJETA should be used as part of a complete treatment regimen for early breast cancer To address new information made available since the 2013 Human Epidermal Growth Factor Receptor 2 (HER2) Testing in Breast Cancer, guideline update a joint, focused update of the clinical practice guideline has been developed by an expert panel of pathologists and oncologists and issued by the American Society of Clinical Oncology and the College of American Pathologists Over 19 months after news of the college admissions scandal initially broke, Lori Loughlin has surrendered to begin what is supposed to be a two-month prison sentence for her involvement, per Variety.A Federal Bureau Of Prisons representative confirmed that the actress arrived to the Dublin, California prison on Friday morning

HER2+ Bröstcancerförbunde

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När Livet förändras: Her2 positiv bröstcancer grad

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